Prognostic classification of Breast carcinoma on molecular basis using ER, PR, Her-2/neu and ki67: A study conducted on 45 patients in RIMS, Ranchi, Jharkhand, India

Objective: To classify the cases of breast carcinoma coming to RIMS, Ranchi into Luminal A,B,Her-2/neu and basal like using IHC Markers-ER,PR,Her-2/neu and ki67 Materials and methods: In our study on 45 patients with breast carcinoma, all of them being women were taken into account and the expression of Hormonal ,markers ER,PR, Her-2 and ki67 were determined by immunohistochemistry and classification into Luminal A,B,Her-2 and Basal like were done subsequently. Results: The mean age of patients was 53.17 years. Of 45 patients, 17 patients (37.77%) had breast cancer with metastasis and 28(62.22%) without metastasis. Nottingham modification of Scarff Bloom Richardson grading was-Grade I in 18 patients, Grade II in 15 patients and Grade III in 12 patients. Depending on IHC markers ER, PR, Her-2/neu and ki67,Luminal A patients were 34(75.55%),Luminal B were 8(17.77%),Her-2/neu1(2.22%) and Basal like-2(4.44%).